Hiv Vaccine, A medical trial in Thailand has raised hopes of a major breakthrough in the fight against Aids after scientists said an experimental vaccine had reduced the risk of HIV infection by a third.
The world’s largest HIV/Aids vaccine trial of more than 16,000 volunteers was the first in which infection has been prevented, according to the US army, which sponsored the trial with the National Institute of Allergy and Infectious Diseases.
A combination of two vaccines was tested on HIV-negative Thai men and women aged 18 to 30 at average risk of becoming infected. All the volunteers were given counselling and condoms to help them avoid HIV. Then half were randomly picked to receive the vaccine, while the other half got dummy shots. Until the trial ended, nobody knew who had been given the genuine vaccine and who had not.
A relatively small number of people became infected with HIV – 51 of the 8,197 people given the vaccine, and in 74 of the 8,198 who received dummy shots – but the difference was statistically significant, which means scientists believe it could not have happened by chance. It worked out at a 31% lower risk of infection for the vaccine group.
Colonel Jerome Kim, who helped to lead the $105m (£64m) study for the US army, said it was “the first evidence that we could have a safe and effective preventive vaccine”.
Recent failures had led many scientists to believe that such a vaccine might not be achievable. In 2007, the drug company Merck abandoned what had looked at the time like the most promising avenue of research after disappointing trial results. Today the National Institute’s director, Dr Anthony Fauci, warned it was “not the end of the road”, but said he was surprised and very pleased by the outcome.
“It gives me cautious optimism about the possibility of improving this result” he said. “This is something that we can do.”
Every day, 7,000 people worldwide are newly infected with HIV; 2 million died of Aids in 2007, the UN agency Unaids estimates.
The Aids Vaccine Advocacy Coalition, an international group that has worked towards developing a vaccine, welcomed the results of the trial, the third major study since 1983, when HIV was identified as the cause of Aids, as “an historic milestone”.
The executive director, Mitchell Warren, said: “There is little doubt that this finding will energise and redirect the Aids vaccine field.”
Frances Gotch, professor of immunology at Imperial College London said the results appeared to be statistically significant and may have been the effect of the two different vaccines working in tandem to more powerful effect.
“The fact that they have seen a response with people with such a low incidence of infection is impressive,” Gotch, who is also the principal investigator for the International Aids Vaccine Initiative, told the Guardian.
“Of course it’s not 100% of people [protected] but 31% could make an enormous difference in the world. I think this is something we can work with.”
Thailand’s ministry of public health conducted the study, which used strains of HIV common in Thailand.
Scientists stressed it was not known whether such a vaccine would work against other strains elsewhere in the world. The study was done in Thailand because US army scientists carried out pivotal research in that country when the Aids epidemic emerged there, isolating virus strains and providing genetic information on them to vaccine Read More
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